Wednesday Fantasy Baseball Lineup Strategies and Betting Insights

by September 16, 2025

Refining Your Fantasy Baseball Lineup

If you’re looking to refine your fantasy baseball lineup, our updated pitcher rankings and selection tools are here to guide you toward making informed decisions. Each morning, we will also provide betting insights for that day’s games. The latest game odds can be tracked through ESPN BET, while our fantasy recommendations target standard ESPN 10-team leagues. Please ensure to verify the accuracy of all data as of the publication time, and for real-time updates or news impacting the day’s MLB action, don’t forget to check the newest developments in fantasy baseball. You’ll find pitching and hitting notes, as well as betting guidance available.

Pitching Notes and Rankings

Our pitching notes rank players based on projected fantasy points (FPTS) as analyzed by the ESPN standard scoring framework. Key metrics include points for wins and innings pitched, and penalties for earned runs and walks, among others. Player’s handedness, opposing teams, roster percentages, the ESPN BET Money Line, and the Over/Under forecast for runs scored are taken into account. If a team opts for an opener followed by a bulk pitcher, the latter is marked accordingly.

Notable Pitchers

Among notable pitchers is David Peterson, who just turned 30 and now serves as a prominent figure in the New York Mets’ rotation. The Mets are clinging to a narrow margin for the final NL Wild Card position as they prepare to compete against the San Diego Padres. Although Peterson has faced challenges in the second half, he has recorded 55 strikeouts while allowing only three home runs in over 53 innings since the All-Star break. His inflated ERA of 5.23 during this period is misleading, as his underlying metrics indicate he has been significantly better. The Padres’ lineup generally struggles against left-handed pitchers, providing a favorable matchup for Peterson.

In another matchup to watch, Brady Singer has shown remarkable consistency, posting quality starts in nine of his last eleven games, including six in a row. With a solid ERA of 3.36 and a WHIP of 1.05 in this stretch—bolstered by impressive strikeout and walk rates—he’s set to face the Cincinnati Reds, who have struggled on the road. Singer will also benefit from a more suitable pitching environment away from his home park.

Meanwhile, Lucas Giolito‘s recent performance may not fully reflect his 2.93 ERA, but it has led to seven victories for the Boston Red Sox across his past ten starts. As they face the Athletics and Mason Barnett, who is not being hailed as a top starter, Giolito has a good chance to secure another win, although he is often prone to gopher balls. Fenway Park mitigates home runs to some extent, and the dropping temperatures in September could further help control that aspect.

Lastly, Cole Ragans is making a return to the rotation after a significant injury absence and is projected for a cautious pitch count in his first outing against the Seattle Mariners. It might be wise to give Ragans time to adjust before making heavy use of him in fantasy lineups.

Player Streaming News

In player streaming news, the Miami Marlins are visiting Coors Field, but none of their hitters are owned in more than 50% of ESPN leagues. Their top four batters—Xavier Edwards, Jakob Marsee, Agustin Ramirez, and Otto Lopez—are potential streaming options, alongside players like Liam Hicks, Heriberto Hernandez, and Connor Norby.

MLB Postseason Brackets

Additionally, create your MLB postseason brackets for a chance to take home a piece of the $50,000 prize pool!